BINKYBUNNY FORUMS > HOUSE RABBIT Q & A > Antibiotics losing effectiveness.
Last Post by bigmak5 at 10/25/2012 9:16 AM (10 Replies)
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User is Offline bigmak5
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9/15/2012 10:31 AM

My rabbit has been on azithromycin for around 3 weeks for a upper respiratory infection. the first 2 weeks he recovered tremendously and the vet wanted to stop the antibiotic but i pushed him to continue treatment so he gave me another 2 week supply and he now is starting to revert slowly back to sneezing but not as bad as it was.has anyone ever heard of a antibiotic that was being administered without interuption stop working? what should i do????

User is Offline BB
San Francisco Bay Area
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9/15/2012 10:05 PM
My bunny, Rucy, went on several different antibiotics (one after the other) when one didn't seem to do job. Her situation was a little different -she did not have URI's - she had jaw abscess issues, and they did a culture and found several different types of bacteria (some that were resistant to some of the antibiotics we had given her, which explained why one type of antibiotic may have worked for a while, but still allowed the other bacteria to flourish.

I don't know if that is what is happening in your bunny's case with a URI or not, but I think you need talk to you vet about what's going on. Is he a rabbit-savvy vet that you trust?

User is Offline Malp_15
British Columbia, Canada
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9/17/2012 10:33 AM
Have you done a culture and sensitivity?

I have a rabbit with chronic URI's that did the same thing at first; 2 weeks on Baytril were great, and then it all went downhill. Once we got the C&S back, it said that he was infected with Bordetella, as well as Pasteurella and that Baytril was not the right antibiotic for him. As well as giving us a list of what antibiotics would work best for him. We ended up going with Tetracycline, but Chloramphenicol was an option too.

User is Offline HappyHopperz
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9/17/2012 12:33 PM

Good topic mentioned here. One of my bunnies, Snicker, has an ongoing case of snuffles. I have spoken with vets over the phone, and have scheduled an appointment in two weeks. What is the most effective medicine to cure snuffles?

User is Offline Sarita
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9/17/2012 12:39 PM
HappyHopperz, Snuffles is just a catch all term for an upper respiratory infection, it's not the actual illness. The best way to find out what bacteria is causing your rabbit "snuffles" is to have a culture and sensitivity test to determine the bacteria and the best medicine to cure it.

User is Offline HappyHopperz
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9/17/2012 12:44 PM
Thank you @Sarita (:. My vet plans to do that test during our visit.

User is Offline bigmak5
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10/17/2012 5:31 AM
Sorry about not responding, my vet took a culture from his ear hopefully they will find something.

User is Offline lzrddr
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10/20/2012 9:58 AM
Chronic respiratory diseases in some rabbits remain just that- chronic. sometimes antibiotics just not seem to have much of an effect.. hard to culture these rabbits with lower respiratory tract diseases, where many of the causative organisms live (in the lungs).. without anesthetizing the rabbit and doing a tracheal/lung wash, a culture is just as likely to show an unrelated bacteria as the organism causing the problem... and even if you did manage to come up with the right bacteria on a culture, that does not mean you will be able to clear the infections... rabbit lungs seem pretty effective in walling off infections (creating chronic abscesses) and even long term antibiotics do not seem to clear those up. Sometimes these rabbits just need to be kept on long term antibiotics (e.g. for years sometimes)

Azithromycin is a great antibiotic for certain lung infections but it is not the only one or necessarily the best.. and few studies have been done on rabbits to determine not only what dose to use, but how long to use it for.. .it is used frequently in people but generally for a strict 5 day treatment period. Not sure why longer treatment is not recommended, but there is likely a good reason for that.. and using it longer in rabbits may be doing more harm than good for all I know.

User is Offline bigmak5
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10/24/2012 9:35 AM
The Test results came back.

One is Serratia Marcesens and the other is Stenotrophomonas Maltiophilia. the vet wants to start him on Trimethprim/Sulfamethoxacole.

Does that sound right?

User is Offline peppypoo
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10/24/2012 6:23 PM
Wow, both rare organisms! Both have been shown to be sensitive to sulfamethoxazole-trimethoprim, so it's definitely worth a shot.
Tammo (RIP), Milo (RIP), Peppy, Remi

User is Offline bigmak5
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10/25/2012 9:16 AM
YEP. sound about right my rabbit has to be unique and individual by catching two unique and individual bactia -_-

BINKYBUNNY FORUMS > HOUSE RABBIT Q & A > Antibiotics losing effectiveness.