Welcome lopdaddy! (now you've been entered in twice for the drawing!)
Okay as for your question - Not weird at all. Very common actually. Many people think their bunny is mad at them when they see changes that seem anti-social. Don't worry she's not mad at you, and she's lucky to have you because you are concerned about her and want her to be happy. There are a few things in your question to cover, so let's take them one by one.
1.) Teenage time: What I think is happening is exactly what you suspected. The teenage years are when their urges to explore become strong. Some bunnies can even become feisty - growl, lunge, bite and scratch as their territorial behaviors dominate with surging hormones. These will die down in time, but may not completely. Spaying will really take care of this. (not to mention that unaltered female rabbits have an extremely high risk of cancer in their reproductive organs.) I am assuming she's not spayed yet?
2) Not wanting to be held anymore/exploring:
I think there are two reasons for this. Because she has less time out, she's anxious to get out and have fun first. I suggest letting her run around and explore for awhile first (unless she's not litter trained yet)
Then the other part of not wanting to be held may be due to the fact she's just growing up. Unfortunately, most adult bunnies don't like being held. Most rabbits only "tolerate" being held. I wish they wanted to be held! I'd snuggle those cute faces in my arms all day. But the truth is that even if a rabbit was used to being held as a baby, doesn't necessarily mean it will enjoy it as an adult. Most don't.
And though getting a bunny to tolerate being held helps with nail clippings etc, if you force your young adult/adult bunny to be held everyday when it no longer wants it, you may actually be creating a negative reaction. Out in open space she may only see you as the "freedom squelcher" and she may end up avoiding you.
I suggest gaining her trust and affection by just grabbing a few pillows and hanging on the floor. Let her run around, get her exercise and need to explore out of her system. Let her come to you. Have a few treats with you, so when she comes over, she will associate you with positive things.
I snuggle with mine on the floor and though it's not the same as holding them, they are happier, and they trust me and they seek me out to get attention. That's the best!
3.) Schedule change: Our lives will always change. We all have to work, and our lives can really get hectic. And sometimes we're just beat! I know you want to be able to give her more time out, and because bunnies really need at least three hours of exercise, what about attaching an x-pen to her cage? If you're worried about her messing up the floor, buy a small square of linoleum, or put a tarp down. (just be sure to keep the edges outside of the pen so she won't chew on them. Both are easy enough to roll up and put away if you only want it there during her playtime.
Is she litter trained yet or is that still challenging since she's not spayed.....or is she?
Oh, I forgot. We are collecting pictures of great set-ups to put in the cool habitat gallery. So if you have any pictures, send 'em over and I'll put them in the gallery.
Those cube types are wonderful aren't they? They look better than a regular rabbit cage (especially since they are going to be in our homes) and they offer our bunnies more room.
Don't be afraid to post long messages. The more information you provide, the better I can help you.